STRN (striatin, calmodulin binding protein)
نویسنده
چکیده
780 amino acids (aa), 86.13 KDa (isoform I) and 731 amino acids, 80.76 KDa (isoform II). Striatin contains a high number of domains mediating protein-protein interactions. Domains: aa 55-63 : Caveolin-binding; aa 53-120 : Coiled-coil; aa 149-166 : Calmodulin-binding; aa 461-500 : WD 1; aa 514-553 : WD 2; aa 567-606 : WD 3; aa 662-701 : WD 4; aa 704-743 : WD 5; aa 750-779 : WD 6 (30 aa only) (Isoform I, according to Swiss-Prot). Caveolin-binding domain: To bind caveolin, a caveolin-binding consensus is necessary: ΦXΦXXXXΦ, ΦXXXXΦXXΦ or ΦXΦXXXXΦXXΦ (Φ corresponding to aromatic amino acid) (Couet et al., 1997). Striatin contains the caveolin-binding consensus motif: LHFIQHEWARF, and binds directly caveolin-1 (Gaillard et al., 2001).
منابع مشابه
Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.
Striatin is an intracellular protein characterized by four protein-protein interaction domains, a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding domain, and a WD repeat domain, suggesting that it is a signaling or a scaffold protein. Down-regulation of striatin, which is expressed in a few subsets of neurons, impairs the growth of dendrites as well as rat locomotor activi...
متن کاملCritical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake.
Striatin is a protein regulator of vesicular trafficking in neurons that also binds caveolin-1 and Ca(2+)-calmodulin and could activate endothelial nitric oxide synthase. We have shown that striatin colocalizes with the mineralocorticoid receptor and that mineralocorticoid receptor activation increases striatin levels in vascular cells. To test whether striatin is a regulator of vascular functi...
متن کاملMolecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines.
Phocein is a widely expressed, highly conserved intracellular protein of 225 amino acids, the sequence of which has limited homology to the sigma subunits from clathrin adaptor complexes and contains an additional stretch bearing a putative SH3-binding domain. This sequence is evolutionarily very conserved (80% identity between Drosophila melanogaster and human). Phocein was discovered by a yea...
متن کاملA novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons
A rat brain synaptosomal protein of 110,000 M(r) present in a fraction highly enriched in adenylyl cyclase activity was microsequenced (Castets, F., G. Baillat, S. Mirzoeva, K. Mabrouk, J. Garin, J. d'Alayer, and A. Monneron. 1994. Biochemistry. 33:5063-5069). Peptide sequences were used to clone a cDNA encoding a novel, 780-amino acid protein named striatin. Striatin is a member of the WD-repe...
متن کاملStriatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.
Steroid hormone receptors (SHRs) are ligand-activated transcription factors that regulate gene expression. SHRs also mediate rapid, nongenomic cellular activation by steroids. In vascular endothelial cells, the SHR for estrogen, estrogen receptor (ER) alpha, is targeted by unknown mechanisms to a functional signaling module in membrane caveolae that enables estrogen to rapidly activate the mito...
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